ΘΕΜΑ: Joint IMBB & ICS Seminar - Ioanna
TRIVIAI, October 2nd 2014 @ 15:00
ΑΠΟΣΤΟΛΕΑΣ: Maria Stiakaki - IMBB Secretariat
[mailto:mariast@xxxxxxxxxxxxx]
JOINT IMBB & ICS
SEMINAR
Dr.
Ioanna TRIVIAI
Junior Group Leader - Stem Cell Biology Group
Clinic of Stem Cell Transplantation, University Medical Center Hamburg
Eppendorf, Hamburg, Germany
And Heinrich – Pette Institut, Leibniz Institute for Experimental
Virology, Hamburg, Hamburg, Germany
Title: "Neoplastic
stem cells in hematopoietic niche disruption: the paradigm of Primary
Myelofibrosis".
Thursday, October 2nd
2014 @ 15:00
Seminar Room 1 [FORTH's
bldg]
ABSTRACT:
Myeloproliferative neoplasms (MPN) are chronic hematological malignancies
characterized by expansion of aberrant myeloid progenitors.
Primary myelofibrosis (PMF) has the worst prognosis of all MPN and involves
massive disruption of the hematopoietic niche leading to
fibrosis/osteosclerosis development and/or transformation to acute myeloid
leukemia (AML). In our studies to elucidate the trigerring event in PMF we
identified a neoplastic stem cell population in patient peripheral blood
responsible for disease initiation and development in vivo. Identifying the
neoplastic stem cells in myeloproliferating neoplasms will provide the basis to
decipher complicated niche
interactions implicated in evolution of the chronic phase and leukemic
transformation and introduce new therapeutical targets to eradicate the
disease.
Hosts:
Dimitris Kafetzopoulos
Post-Genomics Applications Lab
Institute Molecular Biology & Biotechnology
Emmanouil G. Spanakis, PhD.
Computational Medicine Laboratory
Institute of Computer Science